- About Life Cycle
- Life Cycle is an international, peer-reviewed, open access general medical journal and invites submissions of any original contribution that broadens, advances, or brightens medical science or practice, or that educates or delights the Journal’s readers. Building on the foundation of Life Cycle as the best science for medical health research, the Journal is committed to publishing high-quality and cutting-edge Original Research Articles, State-of-the-Art Reviews, and Letters that contribute to the advancement of healthy life from birth to senescence.
CURRENT ISSUE: Sep 2024, Vol. 4
A National trends in type 2 diabetes in South Korea, including the COVID-19 pandemic, 1998-2021: A nationally representative survey study
Life Cycle 2024;4:e7
https://doi.org/10.54724/lc.2024.e7 ABSTRACT
Objective: The COVID-19 pandemic has been associated with worse outcomes for people with diabetes, including increased mortality, while the long-term impact of the pandemic on diabetes prevalence is still underestimated. Thus, we aimed to analyze long-term prevalence trends of type 2 diabetes in South Korea from 1998 to 2021, encompassing the befor... |
Machine-learning prediction of kidney failure occurrence based on regular health check-up data: a nationwide cohort dataset in South Korea
Life Cycle 2024;4:e6
https://doi.org/10.54724/lc.2024.e6 ABSTRACT
Objective: While prior research developed numerous machine learning (ML) models for disease prediction and demonstrated their potential, there has yet to be research on models concerning the prediction of kidney failure and its associated risk factors using simple, regular health check-up data. Thus, this study aimed to develop a ML model capable o... |
Nationwide trends in the prevalence of cataract, glaucoma, and macular degeneration among Korean adults amid the COVID-19 pandemic, 2015-2021: A representative study in South Korea
Life Cycle 2024;4:e5
https://doi.org/10.54724/lc.2024.e5 ABSTRACT
Objective: Understanding the impact of the COVID-19 pandemic on the prevalence of key ocular diseases—cataracts, glaucoma, and macular degeneration—in the general population remains a critical yet understudied area. This study aimed to assess the long-term national prevalence of cataract, glaucoma, and macular degeneration in South Korea, consi... |
National trends in the prevalence of tuberculosis before and during the COVID-19 pandemic, 1998-2021: a nationwide representative study in South Korea
Life Cycle 2024;4:e4
https://doi.org/10.54724/lc.2024.e4 ABSTRACT
Objective: In this study, we investigate changes in the prevalence of tuberculosis (TB) before and during the COVID-19 pandemic in South Korea, analyzing the effects of age, socioeconomic, and environmental variables on TB trends over a period of 24 years. Investigation into the association between TB and the COVID-19 pandemic can accelerate advanc... |
Association between dietary circadian rhythms and metabolic dysfunction-associated steatotic liver disease risk
Life Cycle 2024;4:e3
https://doi.org/10.54724/lc.2024.e3 ABSTRACT
Irregular or late eating patterns have been increasingly associated with a higher risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), which stands as the most prevalent hepatic disorder globally. These eating habits are believed to disrupt the body’s circadian rhythm, a critical factor involved in regulating lipid... |
Association of transitioning from combustible cigarettes to noncombustible nicotine or tobacco products with subsequent cancer risk: a nationwide cohort study in South Korea
Life Cycle 2024;4:e2
https://doi.org/10.54724/lc.2024.e2 |
Trends in prevalence of asthma and COVID-19 pandemic-related factors in South Korea: a post-hoc analysis
Life Cycle 2024;4:e1
https://doi.org/10.54724/lc.2024.e1 ABSTRACT
Objective: There are only a few studies investigating the effects of the COVID-19 pandemic on the prevalence of asthma, especially between different age groups. Thus, we aimed to examine the trends of age-stratified asthma prevalence in South Koreans before and during the COVID-19 pandemic. Methods: This study utilized data derived from the Korea N... |
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MOST CITED ARTICLES
Methods for testing statistical differences between groups in medical research: statistical standard and guideline of Life Cycle Committee
Life Cycle 2022;2:e1
https://doi.org/10.54724/lc.2022.e1 ABSTRACT
In medical research, when independent variables are categorical (i.e., dividing groups), statistical analysis is often required. This situation mostly occurs on randomized controlled trials and observational studies that have multiple patient groups. Also, when analyzing continuous independent variables in a single patient group, breakpoints can be... |
Regression analysis for continuous independent variables in medical research: statistical standard and guideline of Life Cycle Committee
Life Cycle 2022;2:e3
https://doi.org/10.54724/lc.2022.e3 ABSTRACT
Variables measured in medicine are usually continuous, such as blood pressure, serum glucose, and drug dosage. There are statistical methods to confirm whether these variables act as independent variables that cause an outcome. Most of these methods are types of regression analysis. In this article, starting with a simple correlation coefficient, l... |
PRISMA 2020 statement and guidelines for systematic review and meta-analysis articles, and their underlying mathematics: Life Cycle Committee Recommendations
Life Cycle 2022;2:e9
https://doi.org/10.54724/lc.2022.e9 ABSTRACT
The paper discussed the overall aspects of systematic review and meta-analysis and explored the main mathematical context of meta-analysis. This included various methods of analyzing the effect size and obtaining the average effect size depending on the variable type. In doing so, methods of obtaining effect sizes in continuous outcome variables, c... |
Global, regional, and national incidence and mortality of COVID-19 in 237 countries and territories, January 2022: a systematic analysis for World Health Organization COVID-19 Dashboard
Life Cycle 2022;2:e10
https://doi.org/10.54724/lc.2022.e10 ABSTRACT
Objective: To estimate global, regional, and national incidences and mortality of the coronavirus disease 2019 (COVID-19) in 237 countries and territories since the outbreak of the COVID-19 pandemic to 31 January, 2022. Methods: Comprehensive estimates were produced through global, regional, and national studies of cumulative severe acute respirato... |
N-Nitrosodimethylamine-contaminated ranitidine and risk of cancer in South Korea: a nationwide cohort study
Life Cycle 2021;1:e1
https://doi.org/10.54724/lc.2021.e1 ABSTRACT
Objective: On September 2019, the United States Food and Drug Administration announced that some ranitidine products were contaminated with unacceptable levels of N-nitrosodimethylamine (NDMA). We aimed to determine whether the use of ranitidine that was potentially contaminated with NDMA, rather than another histamine H2-receptor antagonist (H2 bl... |
Nationwide COVID-19 vaccination coverage and COVID-19 incidence in South Korea, January 2022: a national official report
Life Cycle 2022;2:e2
https://doi.org/10.54724/lc.2022.e2 ABSTRACT
Objective: To reduce the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severe coronavirus disease 2019 (COVID-19) illness, and COVID-19 related death, all persons in South Korea should stay up to data with recommended COVID-19 vaccinations. This study investigated the rates and effectiveness of the COVID-19 vaccina... |
Global Burden of Disease study at the World Health Organization: research methods for the most comprehensive global study of disease and underlying health policies
Life Cycle 2022;2:e8
https://doi.org/10.54724/lc.2022.e8 ABSTRACT
The Global Burden of Disease (GBD) is a compass that navigates researchers and clinicians in discovering the latest knowledge and the current status of health for populations and countries worldwide. The GBD helps to present various methods in evaluating health-related quality of life and assess the health burden, economic burden, years of life los... |
Propensity score matching for causal inference and reducing the confounding effects: statistical standard and guideline of Life Cycle Committee
Life Cycle 2022;2:e18
https://doi.org/10.54724/lc.2022.e18 ABSTRACT
Since the development of research methodology, there has always been keen interest in developing the accuracy of the research by comparing covariates. Propensity score is useful when the research covers many variables which are not intended to be included as independent variables, thus allowing the removal of certain covariates from the model. This... |
Vaccine strategy against COVID-19 with a focus on the Omicron and stealth Omicron variants: Life Cycle Committee Recommendations
Life Cycle 2022;2:e5
https://doi.org/10.54724/lc.2022.e5 ABSTRACT
The Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), the cause of the pandemic of coronavirus disease 2019 (COVID-19), was first discovered in December 2019 in Wuhan, China, and was consequently transmitted across the world. Further, within a year of its initial discovery, vaccines against SARS-CoV-2 were developed using diverse t... |
The emerging pandemic recent: SARS-CoV-2
Life Cycle 2023;3:e2
https://doi.org/10.54724/lc.2023.e2 ABSTRACT
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), induces coughing, vomiting, or fever. The occurrence, duration, and severity of these symptoms vary from person to person, which makes symptoms of the COVID-19 infection ranging from those of a mild cold to death in severe cases. The cau... |