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1. Introduction
Coronavirus disease 2019 (COVID-19) is a contagious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[1,2] Since its first case was identified in Wuhan, China, on December 1, 2019, the disease spread worldwide, and the World Health Organization declared the outbreak a global pandemic on March 11, 2020. [1-3] The number of confirmed cases has reached 550 million worldwide, with almost 6.33 million deaths thus far.[4] Many countries have implemented strict public health measures in order to prevent and mitigate the transmission of the virus.[5] For example, there have been business hour restrictions, self-isolation measures, social distancing guidelines, mask mandates, nationwide lockdowns, school closures, vaccination recommendations, and many more. It has been almost three years since we have adjusted to the “new normal,” and accordingly, society has experienced a multitude of grave changes.[6] These include changes in both lifestyle and environment, which may affect the onset and exacerbation of respiratory and allergic diseases.[7]
Asthma, allergic rhinitis, and atopic dermatitis are some of the most common causes of chronic illnesses.[8] They are increasing in prevalence, which also adds to the burden of health care costs.[9] South Korea has experienced a great deal of allergic burden in children, for which asthma ranks second in disability-adjusted life years with a score of 13.1 years of life lost.[10] However, some reported a reduction in both emergency department utilization and symptom severity during the pandemic.[11] This article will interpret large-scale data from a population of nearly one million, and produce a comprehensive review in regards to changes in the prevalence of allergic diseases before and during the pandemic.
In our previous paper, we looked at the changes in prevalence up to the beginning of the pandemic.[12,13] In this review paper, we added new observations on the prevalence two years into the pandemic. Since lifestyle and environmental factors have changed as the pandemic period continues, it is meaningful to follow up on the trends in the prevalence of allergic diseases. Many previous studies on the association between allergic diseases and COVID-19 have focused on whether the allergic disease affects SARS-CoV-2 infection and mortality rates, and how to treat infected patients with allergic disease.[14,15] Since the COVID-19 pandemic is continuing and such a pandemic may resurge periodically in the future, tracking the prevalence of allergic diseases during the pandemic will be useful for policy-making and predicting future changes. It is hypothesized that despite COVID-19, the prevalence of allergic disease will increase continuously.
2. Summarize previous findings
Previous study examined the national trends in the prevalence of allergic diseases among Korean adolescents before and during the pandemic.[13] It is important to observe such changes because there is a lack of research about the subsequent impact of the pandemic on allergic diseases. The estimated weighted prevalence of allergic morbidity continuously increased from 2009 to 2019, although there has been a decrease since 2019. In particular, the prevalence of asthma decreased the most rapidly, followed by allergic rhinitis, and lastly atopic dermatitis with the least decrease. The following section will discuss the trends, compare with the previous studies, and evaluate the strengths and weakness of the research. Also we found asthma and atopic dermatitis have decreased in age-standardized prevalence rates from 1990 to 2019, from Global Burden of Diseases study 2019 (Fig. 1 and 2).
3. Plausible mechanism
The prevalence of asthma was continuously declining even before the pandemic. Although there could be different contributing factors, the most plausible mechanisms include improved asthma education, less smoking, and fewer humidifier use. First, there has been a continuous effort by the government and physicians to educate the general public about asthma. There are a total of 17 different Atopy Asthma Education Information Center within Korea that offers effective education and counseling service on the prevention and treatment of atopic dermatitis and asthma.[16] This intervention is comprised of five different main businesses: professional counseling, provision of information on allergy and asthma, provision of education and knowledge, support for atopic dermatitis and asthma prevention projects, monitor risk factors of allergic diseases. The management scheme has helped to reduce the sociocultural and economic burden of asthma through a network that administers the trajectory of the disease. Second, there has been a significant decrease in the use of cigarettes. It is well known that smoking impairs lung function, hence a risk factor for developing symptoms of asthma.[17] This coincides with the results in Table 1 in which the prevalence of smoking decreased by one-third from 2009 to 2011 as compared to 2021. The reduction in smoking is due to National Tobacco Control Program (NTCP) which provides school programs, monitors tobacco control laws, and strengthens cessation facilities. The government policy on smoking has, in turn, helped to decrease the prevalence of asthma due to interdependence. Third, there has been a significant decrease in the use of humidifier disinfectant after the incident in 2011.[18] This was when the link between the unknown deaths and the use of chemicals in humidifier disinfectant by Reckitt Benckiser was proved by authority figures. The chemicals chloromethylisothiazolinone and methylisothiazolinone were associated with several adverse health effects, most notably respiratory diseases such as idiopathic lung fibrosis and asthma.[18] Due to an awareness of this incident, an avoidance of humidifier disinfectant was developed. This resulted in a decreased cumulative irritant effect, which decreased the prevalence of asthma.[19] Therefore, it can be said that the prevalence of asthma decreased over time due to the combination of factors outlined above.
The changes in allergic rhinitis and atopic dermatitis showed similar trends. There are several factors that account for the changes in regard to the increased prevalence of allergic rhinitis and atopic dermatitis before the pandemic. Here, environmental factors account for a large proportion of well-known risk factors for allergic diseases. It is known that the prevalence of such diseases is more frequently reported in high-income countries.[20] One longitudinal study has demonstrated an increase in immunological disorders as a country grows and becomes more affluent.[21] The growth of domestic product has nearly doubled from 2009 to 2021, from 943.94 billion to 1.8 trillion United States Dollars. Therefore, it could be said that the effects of urbanization and industrialization, such as a westernized lifestyle and air pollution, are associated with the increased risk of having allergic diseases.[22] These environmental factors may enhance the abundance of allergens and induce chemical modifications of allergens.[23] These increase oxidative stress in the human body, which is known to be associated with allergic disorders by skewing the immune system towards allergic reactions. The increase in pollen concentration is partially due to climate change and this is correlated with the increase in allergic diseases.[24]
The decrease in the prevalence of asthma, allergic rhinitis and atopic dermatitis could be interpreted as a result of the pandemic and its subsequent measures. There were multiple social distancing measures enacted due to the pandemic,[5] including mask mandates, school closures, reductions in operating hours, restrictions in high-risk areas, and many more. These restriction measures were effective enough to reduce the prevalence of allergic diseases because they acted as a physical barrier that not only reduced transmission but also reduced contact and penetration of allergens.[25,26] Since allergic diseases is a hypersensitive immune system against allergens that involves the overproduction of the immunoglobulin E antibodies. The complete blockage of such allergens will be effective enough to reduce the prevalence of allergic diseases. The allergic diseases are affected by both lifestyle and environmental factors, and the limitation of outdoor activities seemed to have a detrimental effect.[27] Also, there has been a reduction in manufacturing in China after the outbreak, which was one of the most important contributing factors to improving air quality.[28] These factors all combined could explain the downward slope in the prevalence of allergic diseases during the pandemic. In support of this, in atopic dermatitis, where respiratory allergens are not the main etiology, there was less significant decrease in prevalence during the pandemic.
4. Previous studies
There were several studies that also examined the prevalence and trends in allergic diseases. First, there was a study on asthma in Brazil (n=1,434,144).[29] The epidemiological observation study proved that the hospitalization decreased during the pandemic, especially in the pediatric population and the elderly population. This may be due to a reduction in the incidence of many respiratory viral infections impacted by the COVID-19 mitigation strategy. There has been another study in Singapore, which reported a significant and sustained reduction in asthma admissions with a concomitant reduction in respiratory viral infections during the pandemic.[30] The sustained reduction in asthma admissions and PCR-proven respiratory virus infections coincided with the widespread adoption of public health measures during the pandemic. For allergic rhinitis, there has been a study from India (n=128).[31] The report compared the number of patients with symptoms of allergic rhinitis during the pandemic (March to July 2020) and during the preceding three months (January to March 2020) and reported a decrease over two periods. However, the studies above have some limitations which are that they mostly utilize small and heterozygous samples, and that is also a cross-sectional study which is likely to contribute to the inconsistency of the results. However, these previous studies could provide a point of comparison in regards to this current study in Korea.
5. Suggestions
Overall, there has been a decrease in the prevalence of allergic diseases during the examined period. However, more efforts should be made to mitigate the disease further.[32] There was a program in Finland that could be benchmarked in South Korea. Finland has implemented a society-wide (population 5.5 million) proactive program named “The Finnish Allergy Program” to reduce the allergy burden.[32] This program operated for 11 years from 2008 to 2018, and it successfully met government expectations. The program advocated “allergy health” – to have a good life despite allergy. The program was successful: allergic diseases caused fewer symptoms, less disability, and less than 50% of hospitalizations. Similarly, Korea has a society-wide allergy prevention scheme that only targets asthma and atopic dermatitis. This includes monitoring centers in both schools and public health centers that educate and provide medical support to those who suffer from allergic diseases. However, despite the efforts, the prevalence of allergic diseases has not decreased as much compared to that of Finland. Therefore, policymakers should revise their asthma and atopic dermatitis management program. The program should also reflect on allergic rhinitis since it takes up the largest percentage of allergic diseases, although it has less severity. It would be most effective if Korea could utilize Finland’s mitigation strategies so that those who already share the burden of allergic morbidity and those who are susceptible to the disease can be managed effectively.[32]
6. Strengths and weaknesses of previous study
The significance of the study is that this study grasps the prevalence and trends of allergic diseases in the past 13 years.[13] There has been similar research that examines the progression of the diseases, however, there was a lack of evidence during the outbreak. To do so, this research divided the period into seven different categories, with a special emphasis put on the last two years that are classified as the post-COVID-19 period (2020 and 2021). This enables more comprehensive research to take place on allergic diseases.
Nevertheless, there are several limitations to this study. First, this study is specific to South Korea. Since South Korea is a homogenous nation, different races and ethnicities could not be fully encompassed. However, this study does utilize a total of 840,488 individuals, a population that includes adolescents of all types of sociocultural and economic backgrounds. Therefore, the racial and ethnic limitations can be reconsidered given that the data is representative of a unique population to a certain extent. The survey may not account for those who are not enrolled in the public education system. However, the percentage of out-of-school youth in Korea is 4.3 and this is relatively small compared to other countries.[33-35] Therefore, those special cases should be negligible. The second limitation is associated with the nature of the longitudinal study that examines past events, which makes the study inherently prone to several biases. However, much research has proved that the survey has high reliability, which is also supported by its high kappa value. Third, there is a possibility of underdiagnosis due to the nature of the self-reported study because the pandemic decreased medical utilization use frequency. There is a public reluctance to visit hospitals due to the contagious nature of the respiratory disease.[36] There could be concerns that this may affect the results, however, this is highly unlikely because allergic diseases are a form of chronic illness, meaning that the diseases have progressed over a period of time. A single visit to the doctor would not make a dramatic difference in this case, thus this could be regarded as a separate cause that hardly interferes with the prevalence. The cause of the decrease in the prevalence of allergic diseases, which started in 2020 and continued until 2021, is thought to be due to a reduction in contact with allergens caused by wearing a mask and a decrease in air pollution rather than a decrease in access to hospitals. Fourth, although our research examines changes in the prevalence of allergic diseases in light of the pandemic, the study does not show the causal effects of the pandemic. It is hard to conclude that the changes are entirely due to the pandemic. However, the similarities in the two-year trend after the outbreak could potentially indicate that to some extent, the pandemic has accounted for the changes. Finally, it is hard to estimate to what degree the fall in each allergic disease was due to self-isolation, or due to COVID-19 not being a respiratory virus that induces asthma exacerbation. Due to the nature of the survey, it is hard to assess the exact quantity and the extent of influence each factor possesses. This could be further analyzed potentially by separating the variables such as a respiratory virus.
7. Conclusions
To conclude, this study examined the national trends in the prevalence of allergic diseases among Korean adolescents before and during the pandemic.[13] To do so, the KYRBS data from 2009 to 2021 was utilized and various statistical analyses were performed to quantify the extent of change (Table 1). The overall morbidity of allergic diseases showed a continuous increase in the prevalence from 2009 to 2019, followed by a slight decrease after the pandemic. This is because extensive public health measures such as social distancing and mask mandates acted as physical barriers to the transmission of the disease. In light of the findings, we would like to encourage continued efforts to monitor allergic diseases in the years to come, even after the pandemic is over. This understanding of changes in the prevalence of allergic disease before and during the pandemic will provide useful information for establishing policies in another pandemic in the future. It is also recommended that researchers from other countries conduct their own research on the respective topic that can develop a general consensus and confirm the reliability and validity.
