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The effects of systemic corticosteroid on pediatric community-acquired pneumonia: comprehensive review

Jaewoo An1,*, Kyung Suk Baek1, Shinhae Lee1
1Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
*Correspondence: Jae Woo An,

© Copyright 2022 Life Cycle. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: May 02, 2022; Revised: Jun 15, 2022; Accepted: Jun 26, 2022

Published Online: Jul 07, 2022


Community-acquired pneumonia (CAP) is a highly prevalent disorder in children. The treatment options available for children with CAP are inhalation therapy and initiation of appropriate antibiotic therapy. Occasionally, CAP may progress to severe pneumonia despite appropriate therapy. While there are a few studies reporting the beneficial effects of systemic corticosteroids on CAP in adult populations, their effect as adjunctive treatment on CAP in the pediatric population remains unknown. The aim of the present review is to determine the efficacy of systemic corticosteroids on CAP in children where signs, symptoms, and radiographic findings of pneumonia worsened despite appropriate treatment. In our comprehensive review, adjuvant systemic corticosteroid appeared to be effective in reducing morbidity and is associated with clinical and radiographic improvement in children with CAP.

Keywords: Child; community-acquired pneumonia; systemic corticosteroids

1. Introduction

Community-acquired pneumonia (CAP) is one of the most prevalent diseases that remains a severe illness and has a high rate of morbidity and mortality despite antibiotics treatment.[1] The mortality of pneumonia has increased to the point where it became the 3rd most common cause of death in Korea in 2019 (death rate in Korea; 45.1 per 100,000), from the 9th cause in 1999.[2] The increasing medical expenses for CAP has become a significant economic burden on the society.[3] Recent studies have focused on treatment for CAP through early diagnosis and adequate empirical antibiotic therapy according to age, comorbid illness, and severity of illness.[4]

There have been a few studies that determined the effect of corticosteroids as an adjuvant therapy for CAP. A previous study reported that administration of systemic corticosteroids alleviates systemic and pulmonary inflammatory responses in patients with severe pneumonia alongside adequate antibiotic management[5] This implies that anti-inflammatory effect of systemic corticosteroids may improve pneumonia severity and the patient’s outcome such as length of hospital stay.[6] A recent meta-analysis reported that systemic corticosteroid reduced mortality by approximately 3%, and length of hospital stay by 1 day[7], while other studies showed limited evidence which supported the efficacy of systemic corticosteroids in patient with CAP[8]. Some studies even reported increased risk of steroid-related side effects such as super infections and hyperglycemia.[9] Although CAP is a highly prevalent disease in children, there have been no studies determining the effect of systemic corticosteroids on CAP in pediatrics populations.

The aim of this comprehensive review is to investigate the efficacy of systemic corticosteroids administration in children with CAP whose signs and symptoms worsened despite appropriate antibiotic treatment. Our hypothesis is that systemic corticosteroids may reduce systemic inflammation and regulate pro-inflammatory, anti-inflammatory cytokines in children with CAP.

2. CAP definition

CAP is diagnosed when a chest radiograph shows a new pulmonary infiltrate with the presence of acute pneumonia associated with at least one of the following criteria; temperature higher than 38°C or lower than 35°C, new cough with or without sputum production, dyspnea, pleuritic chest pain, or altered breath sound on auscultation[10].

Globally, lower respiratory infections are included in the International Classification of Diseases (ICD)-9 codes (079.6, 466 to 469, 470.0, 480 to 482.8, 483.0 to 483.9, 484.1 to 484.2, 484.6 to 484.7, and 487 to 489) and ICD-10 codes (A48.1, A70, B97.4 to B97.6, J09 to J15.8, J16 to J16.9, J20 to J21.9, J91.0, P23.0 to P23.4, and U04 to U04.9).[11]

3. Global burden of lower respiratory infections

Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 methodology from 1990 to 2019, we evaluated the incidence and mortality in children (5 to 14 years) throughout 204 countries and territories.[12, 13] We reported decreasing trends in incidence rates of lower respiratory infections in children (5 to 14 years) globally (Fig. 1). Furthermore, death rates due to lower respiratory infections appeared to decline between 1990 and 2019 at a global level (Fig. 2). There were 3.27 deaths (95% uncertainty interval [UI], 2.78 to 3.84) reported in 2019 and 7.22 deaths (95% UI 6.06 to 8.34) in 1990 due to lower respiratory infections.

Fig. 1. Annual percent change of lower respiratory infections in children (5 to 14 years), 1990 to 2019.
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Fig. 2. Deaths per 100,000 due to lower respiratory infections in children, both sexes, 1990 to 2019.
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4. Steroid therapy

Previous studies have reported a beneficial effect of systemic corticosteroids in adult patients with CAP. A recent study involving 304 adult patients with CAP, randomly allocated them into the placebo and dexamethasone groups and found a significant reduction in hospital mortality and length of hospital stay in patients with severe CAP who were given a bolus of 5 mg of dexamethasone intravenously for 4 days.[14] Furthermore, a retrospective and observational study determined that mortality decreased in patients with severe CAP who were given systemic corticosteroids (either methylprednisolone or prednisone) along with antibiotic treatment when compared with patients who did not receive systemic corticosteroids.[15] Recently, a randomized, double-blind, placebo-controlled trial assessing adult populations with CAP found that CAP patients treated with corticosteroid had reduced risk of failure of treatment.[16] Corresponding well with previous studies of adult patients with CAP, we found that systemic corticosteroids had a significant effect in reducing systemic inflammation as reflected by a reduced fever within 24 hours of systemic corticosteroids administration (Table 1).[17-19]

Table 1. Comparison of systemic corticosteroids versus no treatment in children for (A) early clinical failure and (B) time to clinical cure
(A) Early clinical failure
Pneumonia Corticosteroids Control Risk ratio (95% CI) Weight I2
Luo 2014 3/15 11/14 0.25 (0.09 to 0.73) 39.14%
Nagy 2013 9/29 18/30 0.52 (0.28 to 0.96) 60.86%
Total 44 44 0.41 (0.24 to 0.70) 100.0% 24.65%
(B) Time to clinical cure (days)
Pneumonia Corticosteroids, mean (SD, N) Control, mean (SD, N) Mean difference (95% CI) Weight I2
Luo 2014 1.9 (0.9, 28) 2.7 (1.1, 30) -0.80 (-1.32 to -0.28) 38.4%
Nagy 2013 2.3 (2.3, 29) 4.3 (2.3, 30) -2.00 (-3.19 to -0.81) 26.12%
Wu 2014 3.2 (1.3, 55) 5.3 (2.2, 53) -2.10 (-2.78 to -1.42) 35.48%
Total 112 113 -1.57 (-2.55 to -0.6) 100.0% 80.23%

CI, confidence interval; SD, standard deviation.

P-values marked with bold indicate statistically significant differences between the groups (P<0.05).

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The systemic anti-inflammatory effects of corticosteroids on the immune system are complex. Possible mechanisms are as the following. First, corticosteroids may modulate secretion of cytokines that play a key role in the pathogenesis of pneumonia. Circulating level of the systemic pro-inflammatory cytokine (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokine (IL-1 receptor antagonist and IL-10) are activated in patients with CAP.[20] The administration of corticosteroids increases anti-inflammatory activity and decreases pro-inflammatory activity in multidimensional ways which include its direct effect by binding of glucocorticoid receptors to glucocorticoid-responsive elements (i.e., the induction of annexin I and MAPK phosphatase 1), indirect effects through the interactions of glucocorticoid receptors with other transcription factors (i.e., NF-kB and activator protein 1) on gene expression, and glucocorticoid receptor-mediated effects on second-messenger cascades (i.e., the PI3K–Akt–eNOS pathway).[21] Therefore, treatment with low doses of corticosteroids interrupts pro-inflammatory cytokine transcription and facilitates anti-inflammatory cytokines transcription.[14, 15, 22, 23] Second, administration of systemic corticosteroids into patients with CAP improves gas-exchange function by relieving fever and modulating excessive aforementioned cytokine responses.[17-19] Third, although the study subjects included in the current study were not admitted to an intensive care unit, there are studies reporting that administering systemic corticosteroids may improve adrenal insufficiency often observed in a high proportion of patients with severe CAP admitted to the intensive care unit.[24] Taken together, corticosteroids may have beneficial effects on the immune response and therefore improve disease severity[14, 22] and decrease febrile duration[25] in the early phase of CAP.

The optimal choice of corticosteroids for adjuvant management in pediatric CAP is currently controversial due to the fact that the use of systemic corticosteroids for CAP in the pediatric population has not been as widely reported as other diseases, such as acute respiratory distress syndrome, bacterial meningitis, and septic shock. A previous case study looking at a 9-year-old girl with severe CAP reported that continuous hydrocortisone infusion in the patient with CAP was effective in mediating the severe inflammatory process.[26] Other studies have suggested that methylprednisolone and prednisolone may have a beneficial effect in reducing morbidity and mortality in antibiotic non-responsive Mycoplasma pneumoniae and some virus-induced pneumonia. [17-19] Our study evaluated the benefits of systemic corticosteroids, which has a longer biological half-life of 36-54 hours and slower reduction of biological response such as intracellular steroid effect and hypothalamic-pituitary-adrenal axis recovery when compared with other corticosteroids.[27, 28]

Despite apparent evidence that systemic corticosteroid has beneficial effects, it may also cause undesirable side effects. A recent study reported adverse effects of systemic steroid in severe pediatric CAP, such as corticosteroid-associated impairment of the host immune response, ultimately resulting in a longer length of hospital stay and higher hospital readmission rates, hypertension, and hyperglycemia.[29] Further research is needed to determine the detrimental effects of systemic corticosteroids in children with CAP.

5. Conclusion

Adequate empirical antibiotic therapy with intravenous administration of systemic corticosteroids as an adjuvant therapy improved clinical signs and symptoms in hospitalized children with CAP without significant side effects. This comprehensive review suggests that systemic corticosteroids treatment may be beneficial for reducing morbidity in hospitalized children with CAP when used with antibiotics.

Capsule Summary

This review article aimed to determine the beneficial effects of systemic corticosteroids in children with community-acquired pneumonia.



Author Contribution

Drs JA, KSB, and SL contributed to the preparation of this review.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Conflicts of Interest

The authors have no conflicts of interest to declare for this study.

Provenance and peer review

Not commissioned; externally peer reviewed.



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