Table 1. Current vaccines in use and in progress, number of doses, schedule, route of administration, developer, and their phases

ID Vaccine platform description Type of contender vaccine Number of doses Schedule Route of administration Developers Phase References
1 Inactivated virus CoronaVac; inactivated SARS-CoV-2 vaccine (vero cell) 2 Day 0 + 14 IM Sinovac Research and Development Co., Ltd Phase 4 [32]
2 Inactivated virus Inactivated SARS-CoV-2 vaccine (Vero cell) 2 Day 0 + 21 IM Sinopharm; Phase 4 A
3 Inactivated virus Inactivated SARS-CoV-2 vaccine (Vero cell), vaccine name BBIBP-CorV 2 Day 0 + 21 IM Sinopharm; Phase 4 [31]
14 Inactivated virus SARS-CoV-2 vaccine (vero cells) 2 Day 0 + 28 IM Institute of Medical Biology + Chinese Academy of Medical Sciences Phase 3 B
15 Inactivated virus QazCovid-in® - COVID-19 inactivated vaccine 2 Day 0 + 21 IM Research Institute for Biological Safety Problems, Rep of Kazakhstan Phase 3 C
20 Inactivated virus BBV152 vaccine 2 Day 0 + 14 IM Bharat Biotech International Limited Phase 3 D
25 Inactivated virus Inactivated SARS-CoV-2 vaccine (Vero cell) 2 Day 0 + 28 IM Shenzhen Kangtai Biological Products Co., Ltd. Phase 3 E
56 Inactivated virus VLA2001 2 Day 0 + 21 IM Valneva, National Institute for Health Research, United Kingdom Phase 3 F
63 Inactivated virus TURKOVAC, inactivated virus 2 Day 0 + 21 IM Erciyes University and the Health Institutes of Turkey (TUSEB) Phase 3 G
4 Viral vector (non-replicating) ChAdOx1-S - (AZD1222) 1-2 Day 0 + 28 IM AstraZeneca + University of Oxford Phase 4 [15]
5 Viral vector (non -replicating) Recombinant novel coronavirus vaccine (adenovirus type 5 vector) 1 Day 0 IM CanSino Biological Inc./Beijing Institute of Biotechnology Phase 4 [13, 14]
6 Viral vector (non -replicating) Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH) 1 Day 0 IH CanSino Biological Inc./Beijing Institute of Biotechnology Phase 3 H
7 Viral vector (non -replicating) Gam-COVID-Vac Adeno-based (rAd26-S+rAd5-S) 2 Day 0 + 21 IM Gamaleya Research Institute ; Health Ministry of the Russian Federation Phase 3 [10]
8 Viral vector (non -replicating) Ad26.COV2.S 1-2 Day 0 or Day 0 +56 IM Janssen Pharmaceutical Phase 4 [17]
38 Viral vector (replicating) DeINS1-2019-nCoV-RBD-OPT1 (Intranasal flu-based-RBD) 2 Day 0 + 28 IN University of Hong Kong, Xiamen University and Beijing Wantai Biological Pharmacy Phase 3 I
9 Protein subunit SARS-CoV-2 rS/Matrix M1-Adjuvant (Full length recombinant SARS CoV-2) 2 Day 0 + 21 IM Novavax Phase 3 [25]
12 Protein subunit Recombinant SARS-CoV-2 vaccine (CHO cell) 2-3 Day 0 + 28 or IM Anhui Zhifei Longcom Biopharmaceutical + Institute of Microbiology, Chinese Academy of Sciences Phase 3 J
22 Protein subunit VAT00008: SARS-CoV-2 S protein with adjuvant 2 Day 0 + 21 IM Sanofi Pasteur + GSK Phase 3 K
29 Protein subunit CpG 1018/Alum-adjuvanted recombinant SARS-CoV-2 trimeric S-protein subunit vaccine (SCB-2019) 2 Day 0 + 21 IM Clover Biopharmaceuticals Inc./Dynavax Phase 3 L
30 Protein subunit COVAX-19® Recombinant spike protein + adjuvant 2 Day 0 + 21 IM Vaxine Pty Ltd./CinnaGen Co. Phase 3 M
31 Protein subunit MVC-COV1901 (Spike-2P protein + adjuvant CpG 1018) 2 Day 0 + 28 IM Medigen Vaccine Biologics + Dynavax + National Institute of Allergy and Infectious Diseases (NIAID) Phase 4 N
33 Protein subunit FINLAY-FR-2 anti-SARS-CoV-2 vaccine (RBD chemically conjugated to tetanus toxoid plus adjuvant) 2 Day 0 + 28 IM Instituto Finlay de Vacunas Phase 3 O
34 Protein subunit EpiVacCorona (EpiVacCorona vaccine based on peptide antigens for the prevention of COVID-19) 2 Day 0 + 21 IM Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" Phase 3 P
35 Protein subunit RBD (baculovirus production expressed in Sf9 cells) recombinant SARS-CoV-2 vaccine (Sf9 Cell) 2 Day 0 + Day 21 + Day 42 IM West China Hospital + Sichuan University Phase 3 Q
55 Protein subunit CIGB-66 (RBD+aluminium hydroxide) 3 Day 0 + 14 + 28 IM Center for Genetic Engineering and Biotechnology (CIGB) Phase 3 R
57 Protein subunit BECOV2 2 Day 0 + 28 IM Biological E. Limited Phase 3 S
60 Protein subunit Recombinant Sars-CoV-2 spike protein, aluminum adjuvanted (Nanocovax) 2 Day 0 + 21 IM Nanogen Pharmaceutical Biotechnology Phase 3 T
61 Protein subunit Recombinant protein vaccine S-268019 (using Baculovirus expression vector system) 2 Day 0 + 21 IM Shionogi Phase 3 U
65 Protein subunit GBP510, a recombinant surface protein vaccine with adjuvant AS03 (aluminium hydroxide) 2 Day 0 + 28 IM SK Bioscience Co., Ltd. and CEPI Phase 3 V
66 Protein subunit Razi Cov Pars, recombinant spike protein 3 Day 0 + 21 +51 IM and IN Razi Vaccine and Serum Research Institute Phase 3 W
91 Protein subunit Recombinant SARS-CoV-2 fusion protein vaccine (V-01) 2 Day 0 + 21 IM Livzon Pharmaceutical Phase 3 X
106 Protein subunit RBD protein recombinant SARS-CoV-2 vaccine (Noora vaccine) 3 Day 0 + 21 + 35 IM Bagheiat-allah University of Medical Sciences/AmitisGen Phase 3 Y
10 RNA based vaccine mRNA-1273 2 Day 0 + 28 IM Moderna + National Institute of Allergy and Infectious Diseases (NIAID) Phase 4 [22]
11 RNA based vaccine BNT162b2 (3 LNP-mRNAs ), also known as "Comirnaty" 2 Day 0 + 21 IM Pfizer/BioNTech + Fosun Pharma Phase 4 [23]
13 RNA based vaccine CVnCoV vaccine 2 Day 0 + 28 IM CureVac AG Phase 3 Z
40 RNA based vaccine SARS-CoV-2 mRNA vaccine (ARCoV) 2 Day 0 + 14 orDay 0 + 28 IM Academy of Military Science (AMS), Walvax Biotechnology and Suzhou Abogen Biosciences Phase 3 AA
78 RNA based vaccine mRNA-1273.351. 3 Day 0 or Day 0 + 28 IM Moderna + National Institute of Allergy and Infectious Diseases (NIAID) Phase 4 BB
115 RNA based vaccine ARCT-154 mRNA vaccine 2 Day 0 + 28 IM Arcturus Therapeutics, Inc. Phase 3 CC
16 DNA based vaccine INO-4800+electroporation 2 Day 0 + 28 ID Inovio Pharmaceuticals + International Vaccine Institute + Advaccine (Suzhou) Biopharmaceutical Co., Ltd Phase 3 [20]
18 DNA based vaccine nCov vaccine 3 Day 0 + 28 + 56 ID Zydus Cadila Phase 3 DD
41 Virus like particle Coronavirus-Like Particle COVID-19 (CoVLP) 2 Day 0 + 21 IM Medicago Inc. Phase 3 EE
53 Live attenuated virus COVI-VAC 1-2 Day 0 orDay 0 + 28 IN Codagenix/Serum Institute of India Phase 3 CC
APC, antigen presenting cell; ID, intradermal; IM, intramuscular; IN, intranasal; IV, inactivated virus; LAV, live-attenuated virus; PS, protein subunit; VVnr, viral vector (non-replicating); VLP, virus like particle; VVr, viral vector (replicating).
A. http://www.chictr.org.cn/showprojen.aspx?proj=56651
B. http://www.chictr.org.cn/showprojen.aspx?proj=56651
C. https://clinicaltrials.gov/ct2/show/NCT04691908
D. https://clinicaltrials.gov/ct2/show/NCT04641481
E. https://clinicaltrials.gov/ct2/show/NCT04852705
F. https://clinicaltrials.gov/ct2/show/NCT04864561
G. https://www.clinicaltrials.gov/ct2/show/NCT04942405?term=TURKOVAC&draw=1.
H. https://clinicaltrials.gov/ct2/show/NCT05124561
I. Chinese Clinical Trial Register (ChiCTR) - The world health organization international clinical trials registered organization registered platform
J. https://www.chictr.org.cn/showprojen.aspx?proj=133228.
K. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=13475 2020
L. https://clinicaltrials.gov/ct2/show/NCT05012787 2021
M. https://en.irct.ir/trial/57559 2021
N. https://clinicaltrials.gov/ct2/show/NCT05079633 2021
O. Eugenia Toledo-Romani M, Garcia-Carmenate M, Silva V, Baldoquin-Rodriguez W, Martínez Pérez M, Rodríguez Gonzalez M, et al. Efficacy and safety of SOBERANA 02, a COVID-19 conjugate vaccine in heterologous three-dose combination. medRxiv. 2021.
P. https://www.clinicaltrials.gov/ct2/show/NCT04780035?term=vaccine&cond=Covid19&draw=2
Q. https://clinicaltrials.gov/ct2/show/NCT04904471 2021
R. https://rpcec.sld.cu/trials/RPCEC00000359-En 2021
S. http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=59772 2022
T. https://clinicaltrials.gov/ct2/show/NCT04922788 2021
U. https://clinicaltrials.gov/ct2/show/NCT05212948
V https://clinicaltrials.gov/ct2/show/NCT05007951 2021
W. https://en.irct.ir/trial/57980
X. https://clinicaltrials.gov/ct2/show/NCT05096832
Y. https://en.irct.ir/trial/60796.
Z. https://clinicaltrials.gov/ct2/show/NCT04674189
AA. https://clinicaltrials.gov/ct2/show/NCT04847102
BB. https://www.clinicaltrialsregister.eu/ctr-search/trial/2021-000930-32/BE
CC. https://www.isrctn.com/ISRCTN15779782
DD. http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=45306&EncHid=&userName=Zydus
EE. https://clinicaltrials.gov/ct2/show/NCT04636697